GI tract current is an enclosed ecosystem where approximately 500 types of bacteria vie for respective allocation and sustenance. The results show that when there are good bacteria (eubiosis), a few of the symptoms are present. However, these PPOs may become a source of dysbiosis if potentially pathogenic organisms dominate them. The normal bacteria colonies can be disturbed by medications (antibiotics, oral contraceptives, etc.), alcohol, and sustained poor diet. Due to the nature of the product being a live bacteria, there are numerous issues with making and distributing probiotics. There are few critical factors that have to be met for a probiotic to be effective: It must survive until the expiration date, reach the intestine intact. BioShield® technology is a unique manufacturing solution designed to provide high quality and performance. Ortho Biotic has a superior shield for the microorganisms so that they are preserved in moisture, heat, light and oxygen during freeze drying. This enables the bacteria to stay inactive until the time they encounter some moisture in the G.I tract. In this manner, through advanced encapsulation, balance is achieved with the penetrating of the target probiotic organisms in its optimum functioning. Ortho Biotic® is a professional strength, broad-spectrum probiotic formula specially formulated to contain alive and active cultures of probiotics that are known to assist in the maintenance of healthy gut flora, preserving the healthy lining of the intestinal tract, and promoting immune health. Contained in this formula is Saccharomyces boulardii, this is a researched microorganism that aids in the restoration of the microflora by improving commensal organisms. There are seven scientifically validated probiotic strains from each Ortho Biotic® capsule because they are selected to be resilient in the stomach acidity and adhere to the intestines as effectively as possible. Suggested Use: Take one capsule daily, preferably with meals or, as advised by a health care professional. Guaranteed potency was demonstrated at expiration among men who followed the recommended dosage instructions. No refrigeration required.